The 48-year-old will be the man in the middle for the EFL Cup clash on Wednesday, the third time he will have been in charge of a meeting between the two city rivals
Mike Dean has been appointed as the referee for the midweek EFL Cup fixture between Manchester United and Manchester City.
The 48-year-old will be overseeing his third Manchester derby, his last being in 2013 as City defeated United 2-1 at Old Trafford with goals from James Milner and Sergio Aguero.
Dean has shown 38 yellow cards thus far in the 2016-17 Premier League season, whilst the one red card he has dished out was to United loanee Adnan Januzaj in Sunderland's defeat to Tottenham.
The Merseysider was the man in the middle as United defeated Leicester City 4-1 in the league back in September, while he awarded two penalties during City's 4-1 victory over Stoke on August 20.